I'll be the first one to admit that Logitech Harmony Remotes are the freaking cat's pajamas, so I am happy to offer up the Logitech Harmony 880 for $116 from Dell Home. The price of the remote is originally $249, but Dell is offering $120 off instantly and another 10 percent off bringing the price down to $116 out the door.
Got a home theatre nut in the family that juggles a couple hundred remote? Get them this remote. They may not forgive you for sleeping with the gardener, but this will get you pretty damn close.