First, you should be safe in continuing to use iTunes as your music organization library. You'll still be able to sync your playlists onto your Pre using one of the apps we detailed here. It's not guaranteed that direct iTunes sync will break in the future, since Palm might still be able to find some kind of workaround; but even if they don't, you have multiple ways of doing it yourself. If you want to be safe, you could just switch over to one of these other library management solutions now, and not have to worry about iTunes anymore. [Gizmodo]

Obviously if you're a Pre user you should not update to the latest iTunes. Not, at least, until Palm strikes back with some kind of firmware update to enable syncing again. It's not like 8.2.1 has all that many new features either, so you don't really need to update. [Pre Thinking]

Update: Here's Palm's official statement:

Palm's media sync works with iTunes 8.2. If Apple chooses to disable media sync in iTunes, it will be a direct blow to their users who will be deprived of a seamless synchronization experience. However, people will have options. They can stay with the iTunes version that works to sync their music on their Pre, they can transfer the music via USB, and there are other third-party applications we can consider.

Update 2: Here's Apple's official statement to Businessweek:

iTunes 8.2.1 is a free software update that provides a number of important bug fixes. It also disables devices falsely pretending to be iPods, including the Palm Pre. As we've said before, newer versions of Apple's iTunes software may no longer provide syncing functionality with unsupported digital media players.