<![CDATA[Gizmodo: stem cells]]> http://tags.gizmodo.com/assets/base/img/thumbs140x140/gizmodo.com.png <![CDATA[Gizmodo: stem cells]]> http://gizmodo.com/tag/stemcells http://gizmodo.com/tag/stemcells <![CDATA[Ten Science Stories That Changed Our Decade]]> There is no doubt that science has become more like science fiction in the past decade, with amazing innovations and discoveries that increased our understanding of the universe. We list ten of the biggest science stories from the past decade.

This was the decade of the first face transplant, the first extinct species brought back from the dead, and printable human tissue; a decade that brought us closer to synthetic life forms and the invisibility cloak. But we've whittled it down to ten of the decade's biggest science stories, with discoveries, advances, and topics that are sure to change our lives in the next ten years.

It's Full of Planets: This was a big decade for planets, and not just because Pluto got a downgrade. In 2005, astronomers discovered Eris, a dwarf planet larger Pluto (as well as smaller dwarf planets Haumea and Makemake). Eris' discovery prompted the International Astronomical Union to actually define the term planet, leading to Pluto's demotion to dwarf planet. But the discovery of Eris after all this time suggests there is still a lot to learn about our solar system.

We also got our first direct look at exoplanets, worlds outside our solar system, thanks to the Hubble Telescope. In 2008, astronomers at the Keck and Gemini captured the first images of planets orbiting distant stars. And the planetary discoveries just keep getting more exciting; just this week, astronomers announced that they had observed a super-Earth that might be made largely of liquid water.

Water, Water Everywhere: The world watched on as the Phoenix Lander dug through the Martian terrain for signs of water on the Red Planet. In the summer of 2008, NASA announced it had found definitive proof of water ice on Mars. More recently, scientists discovered that large deposits of water ice exist beneath the planet's surface. This fall, the moon became the center of our watery attention when astronomers found evidence of water throughout the moon's surface. Although the supervillainous plot to bomb the moon didn't seem as initially impressive as we had hoped, the probe did confirm researchers' suspicions that the moon does, in fact, contain a significant amount of frozen water. These discoveries not only reveal more about our solar system, they indicate that, should humans try to colonize Mars or the moon, there will be resources to make survival a little easier.

Shaking Up the Human Family Tree: Humanity got a new great-great-grandmother (or perhaps she's our great-great-great-aunt) in Ardi, a fossilized hominid skeleton found in Ethiopia. Granted, Ardipithecus ramidus was discovered in 1992, but it wasn't until 2009 that she was revealed as a significant addition to our family tree. Although there's technically no "missing link" because humans didn't evolve from chimpanzees, Ardi is, so far, our closest link to chimps, and brings us closer to the common human-chimp ancestor than ever before. Analysis of Ardi's skeleton and probably anatomy reveals just how unlike either chimps that common ancestor is bound to be. One of the Ardi researchers even quipped that when we find that common ancestor, it might look less like we evolved from a chimp-like creature and more like chimps evolved from creatures more like us.

The Book of Life Recorded: Our understanding of human genetics reached a new milestone with the mapping of the human genome. The Human Genome Project announced a rough draft of the human genome in 2000, followed by a more complete version in 2003; the sequence of the last chromosome was published in 2006. Though the genome hasn't been 100 percent mapped, the Human Genome Project has completed its mapping goals. We still have to interpret the sequences we have recorded, but hopefully as we translate the book of our genetic lives, we will get a better understand of how our genes interact and improve our treatment of genetic diseases. Plus, the project has paved the way for sequencing other critters and plants, and, just this week, the lung cancer and melanoma genomes were sequenced.

Changing Your Genes: The promises of genetic engineering have really begun to bear fruit in the last few years, in ways far beyond Alba, the glowing transgenic bunny that grabbed headlines in 2000. In 1999, an 18-year-old with a, inherited liver disease died during a gene therapy trial, after suffering an unanticipated immune reaction to a viral vector. But in more recent years, gene therapy and genetic engineering have shown their promise. In 2000, scientists reported the first gene therapy success, having provided a patient with severe combine immunodeficiency (commonly known as "Bubble Boy" syndrome), though SCID gene therapy treatments were halted when patients developed leukemia. This year, gene therapy successfully treated children with a congenital form of blindness, giving them the ability to see for the first time in their lives. Meanwhile, genetic engineering experiments on animals have cured color blindness in monkeys, created super-strong monkeys, created drug-producing rats, and enabled animals to pass their altered genes to their offspring.

Stem Cells Grow Up: Embryonic stem cells have been a source of contention for years, but in 2007, Shinya Yamanaka helped sidestep that issue when he found a way to reprogram adult skin cells into induced pluripotent stem cells. Stem cells themselves have continued to aid important medical advances. In 2008, researchers generated motor neurons from elderly patients with ALS, an advance that could help researchers better understand the disease. A newly released study has suggested that a mini stem cell transplant could reverse sickle cell disease, and stem cell research has lead to advances in HIV research and the treatment of heart disease.

Climate Change Takes Center Stage: One of the biggest science stories of the decade has been less about scientific advances than about how the public responds to scientific research. Reports that the glaciers are melting faster than expected, a decade of record warmth, and Al Gore's Nobel Prize have all been part of the conversation on climate change and to what extent humans are responsible.

Commercial Spacecrafts Prepare to Take Flight: Amidst NASA budget cuts, commercial spaceflight has come to the forefront. The Ansari X Prize, first offered in 1996 for the first private enterprise that could fly a three-passenger vehicle 100 kilopmeters into space twice in one week. In 2004, the prize was finally won by Mojave Aerospace Ventures' SpaceShipOne. That same year, Virgin Galactic was founded to further space tourism. The company recently unveiled SpaceShipTwo, the first commercial spacecraft. 2004 also saw the certification of the Mojave Air and Space Port, the first licensed facility for horizontal launches of reusable spacecraft in the US. In anticipation of the spaceflight business, one company claims it's readying a space hotel.

Our Cyborg Present: In the last decade, humans and machines have gotten closer than ever. We have machines that can read our memories, computers that let us type with our brains, and robotic arms controlled by monkey minds. Perhaps the most impressive cyborg advances have come in the last few months, with researchers hooking amputees up to robotic arms that not only respond to electrical signals from the human brain, but also provide tactile feedback.

The LHC Comes Online: The Large Hadron Collider has just begun colliding proton beams, but its construction represents one of the most ambitious scientific undertakings ever. The immense particle accelerator will hopefully give us first-hand observations of aspects of the universe that have been, thus far, the realm of theoretical physics. Despite fears from doomsayers that the LHC would destroy the world and a series of mishaps that led to claims that the device was being sabotaged from the future, the LHC came online this year and quickly got to smashing protons at record-breaking speeds.

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<![CDATA[13 More Embryonic Stem Cell Lines Approved for US Research]]> For the first time in 8 years, US researchers will have access to 13 new lines of embryonic stem cells. The lines meet new ethical requirements and were created from leftover fertility clinic embryos using private money. [BBC and GettyImages]

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<![CDATA[Remainders - Things We Didn't Post]]> Baby Gets Hit By Train, Strolls Away...There's a Hole In My Heart That Can Only Be Filled By—Stem Cells?...Beware Bobbies Bearing BlackBerries...Science Figures Out Why We Break Out Bubbly


Sure it's been the lead story on CNN and a big story on Gawker, but there just wasn't enough DIY mechanics or cellphone-related mayhem for us to pounce on this little gem. As a dad, I don't like seeing shit like this, but knowing there's a happy ending made it a bit easier to view. Oops, did I give too much away? [Gawker]


Hairband balladeers from the roaring '80s will be disappointed to learn that holes in the heart previously only able to be filled by some girl who is already dating some other guy can now be filled by a patch made of stem cells. As for the rest of us, we naturally assumed that if stem cells could give Christopher "Butthole" Reeve real Superman strength and build replica's of Shakey's Pizza, well, of course they can patch heart holes. [PopSci]


By March of next year, many British police officers will be handed a smartphone in order to maintain communication while increasing time in the field. It may work, assuming they block like a million distractions. Frankly, the only reason I wanted to even mention this in Remainders was to remind the world of that stroke of British police genius, Hot Fuzz, through Photoshop. It was that or an image of the gmilfy Prime Suspect herself, Helen Mirren. Did I choose wrong? [BBC via Engadget]


Science produces explanations great and small, and finally got around to one we've been waiting for since Heinrich "Coca" Cola invented the fizzy beverage: Why do we love the carbonation? Everyone used to think it was the exploding carbonation bubbles, but sure enough, it's the carbon dioxide itself—you listening, Al Gore???—that sends a message to open up the sour taste buds, delivering a genuine flavor change. Sure, it's not gadget news, but now, when you head out to the bars, you can order beer in the name of science. [Daily Mail UK]

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<![CDATA[Your Great Great Great Grandkids Might Heal Like Wolverine]]> It sounds straight out of a comic book: Scientists have figured out a way to inject gene-carrying nanoparticles into stem cells in order to make wounds heal faster. I'd get my superheroine costume ready if the method wasn't potentially cancer-causing.

The basic idea is to use nanoparticles to deliver a gene into stem cells which will "encourage new blood vessels to grow so that the tissue stays alive." The results in mice certainly do sound encouraging:

When the modified cells were injected into mice whose hind limbs had been injured, the tissue that regrew to repair the damage had three times the blood vessel density of similar tissue in mice given unmodified cells. Four weeks later, only 20 per cent of the mice given modified cells had lost limbs, compared with 60 per cent in mice that received unmodified cells

The trouble with injecting modified cells like this is that the effects seem to drop off after a period of time. Scientists are looking for other methods, such as using a virus to transmit the gene, but "the viral approach is not without risks–viruses can integrate into the genome of cells and linger permanently, potentially causing cancer or immune reactions." I guess I won't be dashing around town playing heroine anytime soon, but maybe they'll sort out the whole thing in a few generations. [Discover]

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<![CDATA[Forget Dentures, With This Tech You Could Grow New Teeth in Fifty Days]]> I thought this mousey was chewing gum, but it turns out that green lump in its mouth is a fully-functional, bioengineered tooth, the result of "tooth regenerative therapy" research at Tokyo University (of the ear-pulling navigation system fame)

Basically that little mouse, let's call him Jerry, lost a tooth and grew a a new one in its place with the help of some scientists:

To create the new tooth, the researchers [...] took epithelial cells and mesenchymal cells (about 50,000 each) from a mouse embryo and cultivated them together in a collagen-based medium to create a tiny tooth bud - a mass of tissue that has the potential to develop into a tooth.

This mass of tissues was implanted in the spot where Jerry's old tooth used to be and after fifty days that mouse could nibble on cheese properly again. The new tooth grew to the same height as the surrounding ones, is just as hard, and has all the same blood vessels and nerves.

Researchers are hoping that this bioengineering process will one day make dentures and false teeth obsolete, but I think that anyone watching Shark Week is secretly imagining growing a mouthful of chompers like that. [PinkTentacle]

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<![CDATA[Stem Cell Contact Lenses Cure Blindness in Less Than a Month]]> The image associated with this post is best viewed using a browser.Here's something that people with poor or no vision will be excited about: three patients had their sight restored in less than a month by contact lenses cultured with stem cells.

All three patients were blind in one eye. The researchers extracted stem cells from their working eyes, cultured them in contact lenses for 10 days, and gave them to the patients. Within 10 to 14 days of use, the stem cells began recolonizing and repairing the cornea.

Of the three patients, two were legally blind but can now read the big letters on an eye chart, while the third, who could previously read the top few rows of the chart, is now able to pass the vision test for a driver's license. The research team isn't getting over excited, still remaining unsure as to whether the correction will remain stable, but the fact that the three test patients have been enjoying restored sight for the last 18 months is definitely encouraging. The simplicity and low cost of the technique also means that it could be carried out in poorer countries.

This is incredible and potentially game changing. It's stuff like this that makes you realize that we live in the future, and it's awesome. [UNSW via The Australian via GizMag]

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<![CDATA[Beijing Clinic Using Stem Cells as Eternal Youth Beauty Treatment]]> While we debate the morality of stem cell usage here, China's gone ahead and started marketing it as a beauty product. A Beijing medical center is offering "age-reversing" stem cell therapy for your face.

RNL Puhua Plastic and Cosmetic Medical Center is a partner of the Beijing Tian Tan Puhua Hospital, which helps last-hope Parkinson's and spinal cord injury patients. But instead of focusing on that aspect of stem cell therapy, RNL has turned its attention to the multimillion-dollar beauty industry instead.

For about $4000, patients go through a process where fat cells removed from their abdomens are turned into a crop of stem cells. The stem cells are then injected into their faces to plump out skin and erase wrinkles. It sounds like an opposite liposuction. It also sounds like suspiciously iffy science.

Apparently, it's getting pretty popular though. People—South Koreans are specifically mentioned—are allegedly flocking to the center for a chance to have their own fat needled into their faces. [Cityweekend Beijing]

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<![CDATA[Japan Makes First Brain Tissues From Stem Cells]]> Michael J. Fox and other sufferers of degenerative neurological diseases have new hope. Japanese scientists at the government-backed research institute Riken have created the first functioning human brain tissues from stem cells, a step in curing everything from strokes to multiple sclerosis to paralysis. Even better, there may be a chance that these tissues could come from non-embryonic stem cells, which means its research could possibly be continued in the U.S. as well.

Creating actual tissue instead of just cells is an important step since tissue transplants have a better chance of stimulating greater functional recovery in patients. For the moment, Riken researchers are still getting most of their newly minted cerebral cortices from embryonic cells, a big moral and ethical moral battleground over here. But the researchers said that they had harvested some from “induced pluripotent stem cells,” artificially made cells from adult cell cultures – like skin. If so, hopefully one of the last hurdles to growing brains has fallen. [Japan Today]

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<![CDATA[Doctors Using Pig Powder to Regrow a Soldier's Finger]]> While the report of pig bladder powder growing back a man's finger might have been a wee bit exaggerated and/or fabricated, the science behind it is sound. In fact, doctors in Texas are using a pig-based powder, dubbed "Pixie Dust," to try to grow back a soldier's finger.

They aren't sure how well it'll work and are consistently monitoring it, but in theory the powder tricks dormant stem cells in the human body into kicking into gear, growing more of whatever body part they're touching. That means that if it's on skin, it'll grow more skin. If it's on a tendon, it'll regrow tendons. Will it be able to regrow a functioning human finger? And if so, will it work with other body parts such as internal organs? Time will tell. [CNN]

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<![CDATA[Stem Cells Key to Bigger Boobies]]> Who here is a girl/knows a girl who wants implants, but gets spooked by the whole silicone aspect? Well it looks like a couple of Japanese scientists have got your back. Their plan is to combine fat from your thigh with some stem cells. Then they take the "soup" and inject it into each of your mammaries. And presto chango you've got yourself a new rack that looks like pretty damn natural, since it's all you. Leave it Japan to take cutting edge medical tech, and turn it into a way to get bigger boobs.

Stem cells used to boost breasts [BBC]

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