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This Jasco GE Portable 2.1 Digital Speaker System is small and easy to carry around, and provides really nice digital surround sound through just a subwoofer and two satellite speakers. Power is provided by a USB connection, so you don't have to lug around AC power adapters and it comes with bundled software for preset music settings including 3D sound and simulated surround. And for the frequent flyer, the package includes a retractable USB cable and protective pouch. Goes for $80.

Jasco s GE Accessory
Lands Best of Innovations
2006 CES Innovation Award [Jasco Products]