Isabela Merced as Anya Corazon/Spider-Girl

Originally introduced under the codename Araña, Anya was granted mysterious powers and inducted by the Spider Society, an ancient group that worshipped the supernatural totemic animal spider gods that, in some form or another, the Spider-heroes of the multiverse are connected to as avatars (much more on this in a bit). Originally developing superhuman strength and agility alongside the power to manifest a protective exoskeleton, Anya was eventually depowered after renouncing her hunter abilities from the Spider Society, and in a brutal attack when Doomsday Man tore her exoskeleton off of her body, but was given Julia Carpenter’s old costume after she became Madame Web, and officially became Spider-Girl—originally a nickname from Jessica Drew that sticks.
Although Anya operated for a brief while as a powerless hero under the moniker, she gained spider-abilities during the events of Spider-Island, which transformed all of Manhattan into spider-powered people. But while everyone else affected is cured of their abilities at the end of the story, Anya retained her powers, turning her into a fully fledged spider-hero.