Harmony, the maker of several universal remotes, such as the one for the Xbox 360, has teamed up with Harmon Kardon to provide an advanced version of their Harmony 520.
So what justifies the $299 price tag over the $99 on the 520? It's rechargable, it has four more buttons and it's got a color screen. Other than that, the "Harmon Kardon" label may be more acceptable to your wife compared to the "Logitech" on the 520. Other than that, there's no big upgrade difference.
Harman Kardon Unveils Branded Harmony Remote [Zatz not funny]