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21. Indianapolis, Indiana

Image: Sean Pavone
Image: Sean Pavone (Shutterstock)

The average cost of living here is 9% lower than the national average, and the take home for a $100,000 salary is $69,317 after taxes. When you factor in cost-of-living adjustments, that salary goes up to $74,615.

The median price for a house is $230,000.