Based on my experience, the Pad and Quill cases are the toughest of all the gadget cases which imitate Moleskine notebooks. And now there are finally Kindle 3 and Nook versions.
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If the ebook reader cases are as sturdy and durable as the iPhone 4 and iPad versions, then they're great for the clumsy or Moleskine-addicted folks in your life.
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You can get either of the ebook reader cases for $45. [Pad and Quill]