Tadalafil

Better known by the brand name Cialis, tadalafil is primarily prescribed to treat erectile dysfunction, with a longer window of effectiveness (36 hours) than other similar drugs such as Viagra. It can also be used to treat a certain form of high blood pressure and an enlarged prostate.
Though it’s been generic since 2018, the average cash price of a 30-day supply of tadalafil at the pharmacy is still currently around $518. That makes it the most expensive popular generic drug today, according to a recent report from GoodRx. There are reportedly plans to bring an over-the-counter version of it to shelves, which would be cheaper, but that may take years to happen.