Will the events of these films be felt in the MCU?

As we near the end here, it’s time to go big picture. Obviously, the Spider-Verse films have created a language where they are happening parallel to events in the Marvel Cinematic Universe. The MCU is certainly one of the branches of the Spider-Verse. But with such big stuff happening in this one, and the MCU’s Spider-Man at such a cross roads—but also events like Secret Wars on the horizon—could we see a Who Framed Roger Rabbit animation/live-action integration? Anything is possible in the Spider-Verse. Or is it Multiverse?