This cute 800 DPI optical mouse with a built-in speaker slides out like a cellphone to reveal a keypad for VoIP calls. It has an LCD display for Caller ID and switches between mouse and phone functions automatically. It also looks much cooler than other combos we've seen. No word on price or availability. [Product page via Red Ferret]
@ZombieOneZero: You could make a game out of it by trying to talk and dragging the mouse across your face at the same time!
It would be cool if the microphone was on the side and you played voice through your regular speakers so you could use the mouse for both functions at the same time.