The iPhone dictionary famously doesn't take kindly to cussing, but here's a notable exception. This autocorrection takes an insult from the anatomical to the excellently profane, helpfully providing an even more vulgar word in case you need it. [Twitter]
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All you do is create a contact in your phone book, add a nicknames field, and load it up with all the profanity and obscenity you can come up with. I think I've got mine up to like 20 or 30 words.