The Z-Nano mouse is claiming smallest optical mouse in the world: it's about the size of the finger you will use to daintily stab at its buttons. See it in diminutive action.
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Yes, it is clear that the threshold of practicality here has been violated. [TechEBlog via BBG]
DISCUSSION
They should make a "ghost" mouse, that uses a lasers and a camera to track your eye movement. You'll go insane in seconds.