While universal remotes can be hard to program, each being a bit of their own beast, theRCA Voice Control Remote will talk you through the process. And you can talk right back.
During the initial setup, a female voice walks you through the typical configuration of your home theater. And once you're all set up, you can actually give the remote verbal commands like "Turn on DVD"—a command that's customizable in itself, as it can be programmed to activate just the DVD player or every component associated with the DVD player.
The Talking Remote is definitely at least 50% novelty, but I could see it as a nice compromise to handing a technaphobe a full-blown Logitech Harmony. The Talking Remote will be available late this year for an undisclosed price.