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1. New York, New York

Image: shutterupeire
Image: shutterupeire (Shutterstock)

The average cost of living here is 128% higher than the national average. In New York City, residents have a state and a city tax, making the take home for a $100,000 salary $65,700 after taxes. When you factor in cost-of-living adjustments, that salary goes down to $35,791.

The median price for a house is $2.1 million.