From Electrical Signals To Nerve Impulses

To make the hand work, the researchers equipped the artificial hand with sensors that detect information about touch. They achieved this by measuring the tension in artificial tendons that control finger movement, turning these measurements into an electrical current. The level of force could then be measured when the hand was used to grasp an object.

Advertisement

But the central nervous system isn't designed to understand signals like these — they're far too coarse. So, to make this information meaningful, Micera and his team scripted algorithms that can convert these electrical signals into impulses that the sensory nerves can properly interpret. The sense of touch was achieved by sending the digitally enhanced signal through wires into four electrodes that were surgically implanted into the remnants of the nerves in Sørensen's upper arm. He lost his hand nine years ago in a fireworks accident that left the nerves in his arm intact.

"We were worried about reduced sensitivity in Dennis' nerves since they hadn't been used in over nine years," noted Stanisa Raspopovic, first author and scientist at EPFL and SSSA. But these concerns disappeared as the scientists successfully reactivated Sørensen's sense of touch.

Advertisement

"This is the first time in neuroprosthetics that sensory feedback has been restored and used by an amputee in real-time to control an artificial limb," says Micera.

Advertisement

Clinical Trials

A little over a year ago, Sørensen underwent surgery in Rome to have transneural electrodes implanted into the ulnar and median nerves of his left arm. After 19 days of preliminary tests, the researchers connected the prosthetic to the electrodes — and to Sørensen — each day for a week.

Advertisement

These ultra-thin, ultra-precise electrodes relayed extremely weak electrical signals directly into Sørensen's nervous system. The electrodes were painstakingly designed such that they would continue to work even after the formation of post-surgey scar tissue. It also marks the first time in history that electrodes have been transversally implanted into the peripheral nervous system of an amputee.

Advertisement

A World's First

The researchers caution that a sensory-enhanced prosthetic is still years away from being commercially available. Moving forward, the researchers will work to miniaturize the sensory feedback electronics for a more portable version of the prosthetic. They also want to fine-tune the sensory technology for better touch resolution and increased awareness about the angular movement of fingers.

Advertisement

The researchers had to remove the electrodes from Sørensen's arm after one month owing to safety restrictions imposed on clinical trials. That said, the scientists are confident they could remain implanted and functional without damaging the nervous system for years.

Advertisement

So, it'll be a while yet before we see the kind of hyper-realistic cybernetic hands portrayed in science fiction, but between this and other breakthroughs, like artificial skin containing functional blood vessels and lymph capillaries, and mind-controlled prostheses, it's clear we'll get there soon.

Advertisement
Advertisement

Read the entire study at Science Translational Medicine.

Images: Lifehand 2/Patrizia Tocci.

Follow me on Twitter: @dvorsky