A New Sensor Turns Old Microscopes Into Super-Resolution Devices

Illustration for article titled A New Sensor Turns Old Microscopes Into Super-Resolution Devices

‘Image enhance’ just got a little more real, for microscopes at least. A team of researchers form UCLA has developed a new sensor and software that turns an optical microscope into a super-resolution imaging device.

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The new system is referred to as “wavelength scanning pixel super-resolution.” That sounds rather complex, but it’s simple enough: a new kind of sensor captures a stack of separate images, each at a slightly different wavelength of light. Then, software is used to create sub-pixels from the information based on the frequency of light that’s captured.

In the image below, you can see the raw data captured by the sensor on the left, and how it looks after it’s been run through the software on the right.

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Illustration for article titled A New Sensor Turns Old Microscopes Into Super-Resolution Devices

The approach, which is said to work on most traditional lens-based microscopes, provides a resolution of about 250 nanometers across a field of view of about an inch. That’s pretty impressive, and Aydogan Ozcan, one of the researchers, points out in a press release that he “can see and inspect large samples with finer details at the sub-micron level.”

So far the team has tested the technique out on samples of blood cells and cervical smear tests, which also hints at its intended use. The team reckons the device could be retrofitted to devices where budgets are tight—such as clinics in developing countries.

[Light: Science & Applications via PhyOrg]

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DISCUSSION

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RainyDayInterns

While not as impressive, we did convert an “ancient” Unitron inverted scope into something a bit more modern with the help of the EXO attachment and an iPad app.

Here is the old scope: http://rainydaymagazine.com/wp/2014/05/20/…

Here is the scope with the EXO update: http://rainydaymagazine.com/wp/2014/05/22/…