Amazon Women on the Moon (1987)
This goofball homage to the brain-warping experience of watching sci-fi movies on late-night TV came together thanks to five directors (including Gremlins’ Joe Dante and An American Werewolf in London’s John Landis) and a huge ensemble cast. Pfeiffer, starring opposite her then-husband Peter Horton, plays a mom-to-be dealing with a very far-out doctor played by American Werewolf’s Griffin Dunne.