You have Thor, Captain America and Wolverine on one side. Master Chief, Alyx Vance from Half-Life 2, Ash Ketchum and his trusty Pokeball and a blocky guy from Minecraft. It should be no contest, outside of some fancy weapons, the superheroes should destroy any video game character... but do they?
I guess the moral of the story is you can have all the powers you want or insanely powerful weapons but the most powerful weapon is the dude who taps his keyboard to build stuff. Sounds about right. The video called Super Heroes vs Game Heroes was made by CorrorDigital.