The Belkin n52te SpeedPad set the bar for one-handed gaming peripherals that looked like they could control alien spacecraft. It's successor, the Razer Nostromo keypad, maintains the look, and it's been updated to support more instantly-switchable keymaps and gaming profiles.
The Razer Nostromo's got all the new chipsets and drivers that have cropped up since the Belkin Speedpad came out back in 2007, bringing it up to speed with today's cutting-edge competitive gaming (and maintaing its crazy-ass, highly intimidating look.) In addition to its 16 fully-programmable buttons and eight-way directional thumb pad, the Nostromo can now support eight full keymaps (up from three) and twenty gaming profiles (up from ten).
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The new chipset does away with previous limitations on programming, so now all macros can be as long as you want them to be, and a new configuration software makes programming them easier than ever. The Razer Nostromo is available now for $69.99 at Razer Zone. I don't play many PC games but I wouldn't mind just having one on my desk, not plugged into anything. [Razerzone.com]