There are few joys as pure as inhaling helium and talkin' real funny. Well, helium isn't the only gas that changes your voice when you inhale it; sulfur hexafluoride is kind of like the anti-helium, making your voice insanely deep when inhaled. Watch above as Jay Leno and manhunk #372 from Transformers get baritoned. Where can I get me some of this stuff? [Neatorama]
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Sounds like the scene from Young Guns 2 when they were all smokin' peyote and yelling, "Chicken?! Chicken?! You see that chicken?!"