Pretty much everyone can agree that mold looks disgusting, or worse than disgusting. It lays claim to hummus tubs and shower curtains with what feels like intent—it looks alive, possibly because it is. But does this colonizing fungus, beyond its surface-level repellence, actually mean us harm? If you just bit into the refrigerated remains of a sandwich, and came away with a mouthful of mold, should you head to the ER or just vigorously brush your teeth? With instances of mold-linked deaths reported recently at Seattle’s Children Hospital, it’s apparent that how, when, and what kind of mold you encounter (and who you are) matters. For this week’s Giz Asks, we reached out to a number of experts for clarity.
Principal, International Center for Toxicology and Medicine (ICTM)
Is mold dangerous? A far too simplistic question. It’s like asking: are airplanes dangerous? Is bacteria dangerous? Trillions of bacteria live in our intestines and they are essential for our normal function, but if they get into the blood stream, they can be fatal. Molds account for almost 25% of the world’s biomass. They are essential for breaking down plants and trees, returning their vital constituents to the soil. We live in a virtual aerosol of molds which are all around us all of the time. For the most part they are benign. For those who are allergic, they may produce allergy symptoms, no different from dog and cat dander. On occasion they may cause infections which can be quite serious. Histoplasmosis and coccidiomycosis, which occur from outdoor molds in the Ohio and California areas respectively, infect about 1000 individuals per year and cause moderately severe respiratory infections. So, in response to the question: On rare occasions certain molds can produce illness. Overwhelmingly our experience with molds is mostly beneficial and rarely harmful.
Director, Center for Food Safety and Security Systems, University of Maryland
Most molds aren’t dangerous, just as every snake isn’t poisonous. But some are.
The kinds of molds that develop in food—the kinds that make your food look green and fuzzy, or white and fuzzy, etc.—are common in products that are a little bit too moist and and left at room temperature, or left too long in the fridge. These molds might affect taste, and don’t look very appetizing, but most of them aren’t particularly important. I wouldn’t recommend eating them, but if you had a bit by accident it wouldn’t be a problem.
However, there are molds associated with foods that really can be quite dangerous. These are molds that produce a variety of different toxins known collectively as mycotoxins. Probably the most important of these, in terms of public health around the world, is a group of toxins known as aflatoxins. These are quite potent hepatic toxins—liver toxins—and they’re also the most carcinogenic biological agent produced by another biological entity. They’re typically associated with dry products that have been stored with a little too much moisture, and they tend to like warm environments, though they will grow on even a slightly warm day. Corn and peanuts are two of the classic foods that wind up being contaminated like this. There are a lot of requirements and controls put on these kinds of commodities to make sure they’re stored properly and that contaminated products do not enter into the marketplace.
Theoretically, you could take enough of an aflatoxin to kill you within 24 hours. But in reality, to directly damage your liver would require consuming about a milligram a day over the course of a month. This is typically seen in developing countries.
This is the worst of them, but there are literally hundreds of other toxic compounds produced by a small percentage of the molds. Conversely, some molds are actually used in food production—if you take a little bit of the blue part out of blue cheese and put it under a microscope, you’ll actually see the mold growing, and traditional soy sauce is fermented with a mold in order to get the proteins within the soybeans to break down. A lot of it depends on what the mold is growing on.
Professor, Bacteriology and Medical Microbiology and Immunology, University of Wisconsin-Madison
It depends which fungus you’re talking about. Mold is a common name of certain type of filamentous fungi; most people, when they use the word mold, are probably referring to fungi that they see growing on their shower curtains or on food in their refrigerator. But that’s only a tiny representation.
Some fungi produce toxins called mycotoxins in our food substrates, and one of them, for example aflatoxin, is very well-known. It is a liver carcinogen—in fact the most potent natural liver carcinogen known to humankind—and, especially in those countries where governments does not have enough money to monitor the food supply, it can lead to liver cancer.
Aflatoxin invades seed crops like peanuts or corn seed or tree-nuts. Harsh climate conditions—especially heat—can result in high production of it: there are some studies suggesting that climate change will lead to higher aflatoxin production in seed crops.
But there’s a yin-yang here. Aflatoxin is a natural product of fungi that we don’t like, but penicillin is a natural product of fungi that we do like. The accidental discovery, in 1928, of penicillin was utilized to a fantastic degree to keep our troops alive during World War II, and there are many beneficial natural products that come from mold fungi that have been very helpful in fighting disease. So it really depends on the context: where the mold is growing and what the product of the mold is.
Associate Professor, Anatomy of Renewable Materials, Oregon State University
Most molds are not dangerous, in any way. Many people mistake allergic reactions to some type of toxic response. If you dig into the scientific literature you’ll find that the jury is still out even on ‘black mold’ being an issue, with some studies saying it has no effect, and others describing the end of the world.
Fungi are a kingdom. To say molds are dangerous (when people use the word mold to mean fungi), is like saying because some species of spiders are venomous, we should avoid all dogs. Same kingdom… very different creatures.
Deputy Associate Director for Science in the Division of Environmental Health Science & Practice (DEHSP) at the Center for Disease Control and Prevention
Mold has been associated with several health effects. For some people, mold can cause a stuffy nose, sore throat, coughing or wheezing, burning eyes, or skin rash. People with asthma or who are allergic to mold may have severe reactions to mold exposure. Immune-compromised people and people with chronic lung disease may get infections in their lungs from mold.
Inhalation of mold spores, mycelia, fragments of spores and mycelia, and moldy odors (i.e., microbial volatile organic compounds, mVOCs) has been associated with irritant effects in humans regardless of underlying susceptibility. In high concentrations such as those in some farming environments, some fungi can lead to hypersensitivity pneumonitis (e.g., farmer’s lung). However, it is difficult to know what a high concentration is, so our recommendation is to control the moisture source and clean up the mold, regardless of type of mold
We do not use the term “mold poisoning,” but we do know that for people who are sensitive to molds, exposure can lead to symptoms such as stuffy nose, wheezing, and red or itchy eyes, or skin. People with allergies may be more sensitive to molds. Also, individuals with chronic respiratory disease (e.g., chronic obstructive pulmonary disorder, asthma) may experience difficulty breathing. Severe reactions to mold exposure may include fever and shortness of breath. People with immune suppression or underlying lung disease are more susceptible to fungal infections.
In 2004 the Institute of Medicine (IOM) found there was sufficient evidence to link indoor exposure to mold with upper respiratory tract symptoms, cough, and wheeze in otherwise healthy people; with asthma symptoms in people with asthma; and with hypersensitivity pneumonitis in individuals susceptible to that immune-mediated condition. Other recent studies have suggested a potential link of early mold exposure to development of asthma in some children, particularly among children who may be genetically susceptible to asthma development.
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